Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Pax6  paired box 6   (Synonyms: 1500038E17Rik, AEY11, Dey, Dickie's small eye, Gsfaey11, Pax-6)
Results	Reference
1	J:273860 Andreu-Cervera A, Anselme I, Karam A, Laclef C, Catala M, Schneider-Maunoury S, The Ciliopathy Gene Ftm/Rpgrip1l Controls Mouse Forebrain Patterning via Region-Specific Modulation of Hedgehog/Gli Signaling. J Neurosci. 2019 Mar 27;39(13):2398-2415
1	J:154509 Azim E, Jabaudon D, Fame RM, Macklis JD, SOX6 controls dorsal progenitor identity and interneuron diversity during neocortical development. Nat Neurosci. 2009 Oct;12(10):1238-47
1*	J:71879 Bernier G, Vukovich W, Neidhardt L, Herrmann BG, Gruss P, Isolation and characterization of a downstream target of Pax6 in the mammalian retinal primordium. Development. 2001 Oct;128(20):3987-94
1	J:339096 Biswas S, Chan CS, Rubenstein JLR, Gan L, The transcription regulator Lmo3 is required for the development of medial ganglionic eminence derived neurons in the external globus pallidus. Dev Biol. 2023 Aug 1;503:10-24
1	J:303632 Bosze B, Suarez-Navarro J, Soofi A, Lauderdale JD, Dressler GR, Brown NL, Multiple roles for Pax2 in the embryonic mouse eye. Dev Biol. 2021 Apr;472:18-29
1	J:250493 Bunt J, Lim JW, Zhao L, Mason S, Richards LJ, PAX6 does not regulate Nfia and Nfib expression during neocortical development. Sci Rep. 2015 May 29;5:10668
1	J:178178 Bupesh M, Abellan A, Medina L, Genetic and experimental evidence supports the continuum of the central extended amygdala and a mutiple embryonic origin of its principal neurons. J Comp Neurol. 2011 Dec 1;519(17):3507-31
1	J:198655 Cai Z, Tao C, Li H, Ladher R, Gotoh N, Feng GS, Wang F, Zhang X, Deficient FGF signaling causes optic nerve dysgenesis and ocular coloboma. Development. 2013 Jul;140(13):2711-23
1*	J:266589 Cohen-Tayar Y, Cohen H, Mitiagin Y, Abravanel Z, Levy C, Idelson M, Reubinoff B, Itzkovitz S, Raviv S, Kaestner KH, Blinder P, Elkon R, Ashery-Padan R, Pax6 regulation of Sox9 in the mouse retinal pigmented epithelium controls its timely differentiation and choroid vasculature development. Development. 2018 Aug 9;145(15):dev163691
1	J:83530 Dakubo GD, Wang YP, Mazerolle C, Campsall K, McMahon AP, Wallace VA, Retinal ganglion cell-derived sonic hedgehog signaling is required for optic disc and stalk neuroepithelial cell development. Development. 2003 Jul;130(13):2967-80
1	J:30057 Dudley AT, Lyons KM, Robertson EJ, A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye. Genes Dev. 1995 NOV 15;9(22):2795-2807
1	J:54722 Engelkamp D, Rashbass P, Seawright A, van Heyningen V, Role of Pax6 in development of the cerebellar system. Development. 1999 Aug;126(16):3585-96
1	J:311152 Favicchia I, Flore G, Cioffi S, Lania G, Baldini A, Illingworth E, Pharmacological Rescue of the Brain Cortex Phenotype of Tbx1 Mouse Mutants: Significance for 22q11.2 Deletion Syndrome. Front Mol Neurosci. 2021;14:663598
1	J:241099 Flore G, Cioffi S, Bilio M, Illingworth E, Cortical Development Requires Mesodermal Expression of Tbx1, a Gene Haploinsufficient in 22q11.2 Deletion Syndrome. Cereb Cortex. 2017 Mar 01;27(3):2210-2225
1	J:47285 Galili N, Epstein JA, Leconte I, Nayak S, Buck CA, Gscl, a gene within the minimal DiGeorge critical region, is expressed in primordial germ cells and the developing pons. Dev Dyn. 1998 May;212(1):86-93
1	J:206763 Gan Q, Lee A, Suzuki R, Yamagami T, Stokes A, Nguyen BC, Pleasure D, Wang J, Chen HW, Zhou CJ, Pax6 mediates ss-catenin signaling for self-renewal and neurogenesis by neocortical radial glial stem cells. Stem Cells. 2014 Jan;32(1):45-58
1	J:228726 Golonzhka O, Nord A, Tang PL, Lindtner S, Ypsilanti AR, Ferretti E, Visel A, Selleri L, Rubenstein JL, Pbx Regulates Patterning of the Cerebral Cortex in Progenitors and Postmitotic Neurons. Neuron. 2015 Dec 16;88(6):1192-207
1*	J:91257 Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk DI, Tsung EF, Cai Z, Alberta JA, Cheng LP, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, Greenberg ME, McMahon AP, Rowitch DH, Stiles CD, Ma Q, Mouse Brain Organization Revealed Through Direct Genome-Scale TF Expression Analysis. Science. 2004 Dec 24;306(5705):2255-2257
1	J:253278 Greig LC, Woodworth MB, Greppi C, Macklis JD, Ctip1 Controls Acquisition of Sensory Area Identity and Establishment of Sensory Input Fields in the Developing Neocortex. Neuron. 2016 Apr 20;90(2):261-77
1*	J:51693 Grimm C, Chatterjee B, Favor J, Immervoll T, Loster J, Klopp N, Sandulache R, Graw J, Aphakia (ak), a mouse mutation affecting early eye development: fine mapping, consideration of candidate genes and altered Pax6 and Six3 gene expression pattern. Dev Genet. 1998;23(4):299-316
1*	J:49133 Hallonet M, Hollemann T, Wehr R, Jenkins NA, Copeland NG, Pieler T , Gruss P, Vax1 is a novel homeobox-containing gene expressed in the developing anterior ventral forebrain. Development. 1998 Jul;125(14):2599-610
1	J:326662 Hamed AA, Kunz DJ, El-Hamamy I, Trinh QM, Subedar OD, Richards LM, Foltz W, Bullivant G, Ware M, Vladoiu MC, Zhang J, Raj AM, Pugh TJ, Taylor MD, Teichmann SA, Stein LD, Simons BD, Dirks PB, A brain precursor atlas reveals the acquisition of developmental-like states in adult cerebral tumours. Nat Commun. 2022 Jul 19;13(1):4178
1	J:307953 Hu L, Chen Y, Yang CP, Huang Y, Song NN, Chen JY, Sun YL, Ding YQ, Lang B, Ulk4, a Newly Discovered Susceptibility Gene for Schizophrenia, Regulates Corticogenesis in Mice. Front Cell Dev Biol. 2021;9:645368
1	J:222296 Huang Y, Yu X, Sun N, Qiao N, Cao Y, Boyd-Kirkup JD, Shen Q, Han JD, Single-cell-level spatial gene expression in the embryonic neural differentiation niche. Genome Res. 2015 Apr;25(4):570-81
1*	J:311233 Huang YT, Mason JO, Price DJ, Lateral cortical Cdca7 expression levels are regulated by Pax6 and influence the production of intermediate progenitors. BMC Neurosci. 2017 Jun 5;18(1):47
1	J:144066 Joshi PS, Molyneaux BJ, Feng L, Xie X, Macklis JD, Gan L, Bhlhb5 regulates the postmitotic acquisition of area identities in layers II-V of the developing neocortex. Neuron. 2008 Oct 23;60(2):258-72
1	J:155751 Kang W, Wong LC, Shi SH, Hebert JM, The transition from radial glial to intermediate progenitor cell is inhibited by FGF signaling during corticogenesis. J Neurosci. 2009 Nov 18;29(46):14571-80
1*	J:70346 Kim AS, Anderson SA, Rubenstein JL, Lowenstein DH, Pleasure SJ, Pax-6 regulates expression of SFRP-2 and Wnt-7b in the developing CNS. J Neurosci. 2001 Mar 1;21(5):RC132
1	J:58952 Kioussi C, O'Connell S, St-Onge L, Treier M, Gleiberman AS, Gruss P, Rosenfeld MG, Pax6 is essential for establishing ventral-dorsal cell boundaries in pituitary gland development. Proc Natl Acad Sci U S A. 1999 Dec 7;96(25):14378-82
1	J:225435 Laclef C, Anselme I, Besse L, Catala M, Palmyre A, Baas D, Paschaki M, Pedraza M, Metin C, Durand B, Schneider-Maunoury S, The role of primary cilia in corpus callosum formation is mediated by production of the Gli3 repressor. Hum Mol Genet. 2015 Sep 1;24(17):4997-5014
1	J:104339 Li X, Perissi V, Liu F, Rose DW, Rosenfeld MG, Tissue-specific regulation of retinal and pituitary precursor cell proliferation. Science. 2002 Aug 16;297(5584):1180-3
1	J:208651 Louvi A, Nishimura S, Gunel M, Ccm3, a gene associated with cerebral cavernous malformations, is required for neuronal migration. Development. 2014 Mar;141(6):1404-15
1	J:206284 Lu KM, Evans SM, Hirano S, Liu FC, Dual role for Islet-1 in promoting striatonigral and repressing striatopallidal genetic programs to specify striatonigral cell identity. Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):E168-77
1*	J:60773 Lu QR, Yuk D, Alberta JA, Zhu Z, Pawlitzky I, Chan J, McMahon AP, Stiles CD, Rowitch DH, Sonic hedgehog--regulated oligodendrocyte lineage genes encoding bHLH proteins in the mammalian central nervous system. Neuron. 2000 Feb;25(2):317-29
1	J:268025 Makeyev EV, Zhang J, Carrasco MA, Maniatis T, The MicroRNA miR-124 promotes neuronal differentiation by triggering brain-specific alternative pre-mRNA splicing. Mol Cell. 2007 Aug 3;27(3):435-48
1	J:170543 Matsushima D, Heavner W, Pevny LH, Combinatorial regulation of optic cup progenitor cell fate by SOX2 and PAX6. Development. 2011 Feb;138(3):443-54
1	J:261809 Mayer C, Hafemeister C, Bandler RC, Machold R, Batista Brito R, Jaglin X, Allaway K, Butler A, Fishell G, Satija R, Developmental diversification of cortical inhibitory interneurons. Nature. 2018 Mar 22;555(7697):457-462
1	J:193058 Miguez A, Ducret S, Di Meglio T, Parras C, Hmidan H, Haton C, Sekizar S, Mannioui A, Vidal M, Kerever A, Nyabi O, Haigh J, Zalc B, Rijli FM, Thomas JL, Opposing roles for Hoxa2 and Hoxb2 in hindbrain oligodendrocyte patterning. J Neurosci. 2012 Nov 28;32(48):17172-85
1	J:98488 Mui SH, Kim JW, Lemke G, Bertuzzi S, Vax genes ventralize the embryonic eye. Genes Dev. 2005 May 15;19(10):1249-59
1	J:38554 Nagai T, Aruga J, Takada S, Gunther T, Sporle R, Schughart K , Mikoshiba K, The expression of the mouse Zic1, Zic2, and Zic3 gene suggests an essential role for Zic genes in body pattern formation. Dev Biol. 1997 Feb 15;182(2):299-313
1	J:242339 Ohayon D, Garces A, Joly W, Soukkarieh C, Takagi T, Sabourin JC, Agius E, Darling DS, De Santa Barbara P, Higashi Y, Stolt CC, Hugnot JP, Richardson WD, Carroll P, Pattyn A, Onset of Spinal Cord Astrocyte Precursor Emigration from the Ventricular Zone Involves the Zeb1 Transcription Factor. Cell Rep. 2016 Nov 01;17(6):1473-1481
1	J:119651 Pan Y, Woodbury A, Esko JD, Grobe K, Zhang X, Heparan sulfate biosynthetic gene Ndst1 is required for FGF signaling in early lens development. Development. 2006 Dec;133(24):4933-44
1*	J:109515 Paracchini S, Thomas A, Castro S, Lai C, Paramasivam M, Wang Y, Keating BJ, Taylor JM, Hacking DF, Scerri T, Francks C, Richardson AJ, Wade-Martins R, Stein JF, Knight JC, Copp AJ, Loturco J, Monaco AP, The chromosome 6p22 haplotype associated with dyslexia reduces the expression of KIAA0319, a novel gene involved in neuronal migration. Hum Mol Genet. 2006 May 15;15(10):1659-66
1*	J:309436 Parish EV, Mason JO, Price DJ, Expression of Barhl2 and its relationship with Pax6 expression in the forebrain of the mouse embryo. BMC Neurosci. 2016 Nov 25;17(1):76
1	J:228045 Puelles L, Kuwana E, Puelles E, Bulfone A, Shimamura K, Keleher J, Smiga S, Rubenstein JL, Pallial and subpallial derivatives in the embryonic chick and mouse telencephalon, traced by the expression of the genes Dlx-2, Emx-1, Nkx-2.1, Pax-6, and Tbr-1. J Comp Neurol. 2000 Aug 28;424(3):409-38
1*	J:55320 Puelles L, Kuwana E, Puelles E, Rubenstein JL, Comparison of the mammalian and avian telencephalon from the perspective of gene expression data. Eur J Morphol. 1999 Apr;37(2-3):139-50
1*	J:56583 Ring BZ, Cordes SP, Overbeek PA, Barsh GS, Regulation of mouse lens fiber cell development and differentiation by the Maf gene. Development. 2000 Jan;127(2):307-17
1	J:87739 Rutherford AD, Dhomen N, Smith HK, Sowden JC, Delayed expression of the Crx gene and photoreceptor development in the Chx10-deficient retina. Invest Ophthalmol Vis Sci. 2004 Feb;45(2):375-84
1	J:339441 Sansom SN, Hebert JM, Thammongkol U, Smith J, Nisbet G, Surani MA, McConnell SK, Livesey FJ, Genomic characterisation of a Fgf-regulated gradient-based neocortical protomap. Development. 2005 Sep;132(17):3947-61
1*	J:93057 Schuurmans C, Armant O, Nieto M, Stenman JM, Britz O, Klenin N, Brown C, Langevin LM, Seibt J, Tang H, Cunningham JM, Dyck R, Walsh C, Campbell K, Polleux F, Guillemot F, Sequential phases of cortical specification involve Neurogenin-dependent and -independent pathways. EMBO J. 2004 Jul 21;23(14):2892-902
1*	J:55154 Schwarz M, Alvarez-Bolado G, Dressler G, Urbanek P, Busslinger M, Gruss P, Pax2/5 and Pax6 subdivide the early neural tube into three domains. Mech Dev. 1999 Apr;82(1-2):29-39
1	J:168035 Shikata Y, Okada T, Hashimoto M, Ellis T, Matsumaru D, Shiroishi T, Ogawa M, Wainwright B, Motoyama J, Ptch1-mediated dosage-dependent action of Shh signaling regulates neural progenitor development at late gestational stages. Dev Biol. 2011 Jan 15;349(2):147-59
1	J:58977 Simmons CP, Mastroeni P, Fowler R, Ghaem-maghami M, Lycke N, Pizza M, Rappuoli R, Dougan G, MHC class I-restricted cytotoxic lymphocyte responses induced by enterotoxin-based mucosal adjuvants. J Immunol. 1999 Dec 15;163(12):6502-10
1	J:86868 Simon R, Lufkin T, Postnatal lethality in mice lacking the Sax2 homeobox gene homologous to Drosophila S59/slouch: evidence for positive and negative autoregulation. Mol Cell Biol. 2003 Dec;23(24):9046-60
1*	J:65195 Stoykova A, Treichel D, Hallonet M, Gruss P, Pax6 modulates the dorsoventral patterning of the mammalian telencephalon. J Neurosci. 2000 Nov 1;20(21):8042-50
1	J:50974 Sun T, Pringle NP, Hardy AP, Richardson WD, Smith HK, Pax6 influences the time and site of origin of glial precursors in the ventral neural tube. Mol Cell Neurosci. 1998 Nov;12(4-5):228-39
1*	J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
1*	J:104160 Tole S, Gutin G, Bhatnagar L, Remedios R, Hebert JM, Development of midline cell types and commissural axon tracts requires Fgfr1 in the cerebrum. Dev Biol. 2006 Jan 1;289(1):141-51
1*	J:34768 Tremblay P, Pituello F, Gruss P, Inhibition of floor plate differentiation by Pax3: evidence from ectopic expression in transgenic mice. Development. 1996 Aug;122(8):2555-67
1*	J:52751 Tuttle R, Nakagawa Y, Johnson JE, O'Leary DD, Defects in thalamocortical axon pathfinding correlate with altered cell domains in Mash-1-deficient mice. Development. 1999 May;126(9):1903-16
1*	J:1914 Walther C, Gruss P, Pax-6, a murine paired box gene, is expressed in the developing CNS. Development. 1991 Dec;113(4):1435-49
1	J:241749 Wilson SL, Wilson JP, Wang C, Wang B, McConnell SK, Primary cilia and Gli3 activity regulate cerebral cortical size. Dev Neurobiol. 2012 Sep;72(9):1196-212
1	J:313451 Xu L, Zheng Y, Li X, Wang A, Huo D, Li Q, Wang S, Luo Z, Liu Y, Xu F, Wu X, Wu M, Zhou Y, Abnormal neocortex arealization and Sotos-like syndrome-associated behavior in Setd2 mutant mice. Sci Adv. 2021 Jan;7(1)
1*	J:51130 Xu PX, Zhang X, Heaney S, Yoon A, Michelson AM, Maas RL, Regulation of Pax6 expression is conserved between mice and flies. Development. 1999 Jan;126(2):383-95
1	J:213336 Yan X, Sabrautzki S, Horsch M, Fuchs H, Gailus-Durner V, Beckers J, Hrabe de Angelis M, Graw J, Peroxidasin is essential for eye development in the mouse. Hum Mol Genet. 2014 Nov 1;23(21):5597-614
1	J:203728 Zembrzycki A, Chou SJ, Ashery-Padan R, Stoykova A, O'Leary DD, Sensory cortex limits cortical maps and drives top-down plasticity in thalamocortical circuits. Nat Neurosci. 2013 Aug;16(8):1060-7
1*	J:73070 Zhao S, Hung FC, Colvin JS, White A, Dai W, Lovicu FJ, Ornitz DM, Overbeek PA, Patterning the optic neuroepithelium by FGF signaling and Ras activation. Development. 2001 Dec;128(24):5051-60
1	J:309104 Zheng MH, Shi M, Pei Z, Gao F, Han H, Ding YQ, The transcription factor RBP-J is essential for retinal cell differentiation and lamination. Mol Brain. 2009 Dec 18;2:38
1	J:344238 Zheng Y, Zhao C, Song Q, Xu L, Zhang B, Hu G, Kong X, Li S, Li X, Shen Y, Zhuang L, Wu M, Liu Y, Zhou Y, Histone methylation mediated by NSD1 is required for the establishment and maintenance of neuronal identities. Cell Rep. 2023 Dec 26;42(12):113496
1	J:71195 Zhou C, Tsai SY, Tsai MJ, COUP-TFI: an intrinsic factor for early regionalization of the neocortex. Genes Dev. 2001 Aug 15;15(16):2054-9